Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis

摘要: Background Pulmonary embolism (PE) is correlated with increased mortality among patients lung cancer (LC). The characteristics of LC presenting PE have not been fully established, and our meta-analysis aims to comprehensively investigate the clinical associated in help physicians identify earlier these patients. Methods Multiple databases were searched, including PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure Wanfang. Odds ratios (ORs) weighted mean differences (WMDs) 95% confidence intervals (95% CIs) used as effect measures for dichotomous continuous variables, respectively. Moreover, Egger’s test, Begg’s test a sensitivity analysis performed assess publication bias reliability articles. Results In total, 16 studies included meta-analysis. results indicated that history chronic obstructive pulmonary disease (OR = 2.59, CI: 1.09, 6.15; P 0.03), adenocarcinoma 2.28, 1.88, 2.77; < 0.01), advanced tumour stage (TNM III-IV vs. I-II, OR 2.38, 1.99, 2.86; central venous catheter 1.95, 1.36, 2.78; chemotherapy 2.32, 1.80, 2.99, high levels D-dimer (WMD 4.31, 2.53, 6.10; 0.01) carcinoembryonic antigen 10.30, 9.95, 10.64; low level partial pressure oxygen -25.97, -31.31, -20.62; features compared those without PE. Conclusions These reveal specific features, but limited several cancer- treatment-related factors, may their early identification.