In Vivo Suppression by Cholera Toxin of Cell-Mediated and Foreign Body Inflammatory Responses

摘要: Cholera toxin (CT) injected i.v. into mice resulted in a rise cyclic AMP levels splenic white cells. This was associated with and followed by marked relatively prolonged decrease both the spleen cells circulating lymphocytes. The effect of CT on series cell-mediated immunologic reactions related to pathogenesis schistosomiasis then tested. profoundly suppressed dermal footpad swelling soluble schistosome egg antigens, granuloma formation around eggs pulmonary microvasculature unsensitized sensitized mice, production macrophage migration inhibition factor intact granulomas (obtained from livers infected mice) maintained vitro tissue culture, it ameliorated portal hypertension esophageal varices hepatosplenic schistosomiasis. In addition significantly allograft survival even though first administered 6 days after grafting. Finally, completely eliminated foreign body plastic beads (used as controls for granulomas) which is nonimmunologic reaction due activation chemical mediators inflammation.