The activation of the C3b feedback cycle with human complement components. II. Using components of the alternative pathway.

摘要: The C3 convertase of the C3b feedback cycle was generated in fluid phase from and factors B D. It shown to be an effective decomplementing agent when reacted with human serum. Many effects observed were dependent on operation during ongoing reaction. Oxidization factor iodine did not significantly increase potency or stability enzyme. Treatment antrypol inhibited formation In preliminary experiments rat, successfully formed vivo, accompanied by cleavage C3, consumption C5, C6 C7, a biphasic change circulating neutrophils.