Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics

摘要: Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathological characteristics. In this study, real-time polymerase chain reaction applied analyze five SNPs rs1990172, rs975263, rs3095007, rs4721888, rs3735615 378 patients with 1199 cancer-free controls. The results showed that 151 among smokers who carried rs1990172 "CA + AA" variants had lower risk developing large tumor (odds ratio [OR] = 0.375, p 0.026), more advanced clinical stage ([OR] 0.390, p=0.032), invasion 0.198, 0.034). 137 drinkers rs4721888 "GC CC" higher develop 3.780, 0.009). Further analyses revealed statistical significance aberrant AST/ALT rs975263 "AG+GG" before adjustment age alcohol drinking. conclusion, our are involved progression may serve or predictor prognosis.