Quinoxaline and quinoxaline-1,4-di-N-oxides: An emerging class of antimycobacterials.

摘要: Tuberculosis (TB) is a highly dreaded, infectious, chronic, airborne disease affecting more than two million people all around the world, with eight cases every calendar year. TB second leading infectious cause of death after HIV/AIDS. Over past few decades, numerous efforts have been undertaken to develop new anti-TB agents. The current frontline therapy for consists administering three or different drugs (usually isoniazid, rifampin, pyrazinamide, and ethambutol) over an extended period time. But these will take 6-12 months cure TB, along many side effects; hence, there urgent need explore Quinoxaline derivatives are class compounds that show spectrum biological properties interest in exponentially growing within field medicinal chemistry. Quinoxaline-1,4-di-N-oxide shown improve results endowed anti-viral, anti-cancer, anti-bacterial, anti-protozoal activities application other therapeutic areas. Since quinoxaline regarded as effective candidates, their 1,4-di-N-oxide analogues may promising vitro vivo might be able prevent drug resistance certain extent. Therefore, main aim this review focus on important quinoxaline-1,4-di-N-oxide activities, structure-activity relationships designing agents better efficacies. present helpful providing insights rational designs active less toxic quinoxaline-based prodrugs.