Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia

摘要: Induced pluripotent stem cells (iPSCs) are a self-renewable pool of derived from an organism's somatic cells. These can then be programmed to other cell types, including neurons. Use iPSCs in research has been two-fold as they have used for human disease modelling well the possibility generate new therapies. Particularly complex diseases, such neurodegenerative give advantages over traditional animal models that more accurately represent genome. Additionally, patient-derived modified using gene editing technology and further transplanted brain. Glial recently become important avenues field example, Alzheimer's Parkinson's disease. This review focuses on glial (astrocytes, microglia, oligodendrocytes) order better understanding how these contribute pathology. Using glia vitro culture, cerebral organoids, intracranial transplantation may us future insight into both accurate disease-modifying