Increased risk of atherosclerosis in women after the menopause.
作者： J. C. Witteman , D. E. Grobbee , F. J. Kok , A. Hofman , H. A. Valkenburg
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摘要: An increase in the incidence of cardiovascular disease has generally been observed postmenopausal women, but there have few studies association between menopausal state and atherosclerosis. In this study 294 premenopausal 319 women aged 45 to 55 were examined radiographically for calcified deposits abdominal aorta, which shown represent intimal Aortic atherosclerosis was present eight (3%) 38 (12%) women. After adjustments age other indicators risk with a natural menopause had 3.4 times greater than (95% confidence interval 1.2 9.7; p less 0.05); who bilateral oophorectomy 5.5 (1.9 15.8; 0.005). No excess among hysterectomy without removal both ovaries. These results suggest that when oestrogen production stops, either naturally or after surgery, is increased.
sci-hub.se 参考文章(11)
JacquelineC.M. Witteman, FransJ. Kok, JanL.C.M. Van Saase, HansA. Valkenburg, AORTIC CALCIFICATION AS A PREDICTOR OF CARDIOVASCULAR MORTALITY The Lancet. ,vol. 328, pp. 1120- 1122 ,(1986) , 10.1016/S0140-6736(86)90530-1
WILLIAM B. KANNEL, Menopause and Risk of Cardiovascular Disease Annals of Internal Medicine. ,vol. 85, pp. 447- 452 ,(1976) , 10.7326/0003-4819-85-4-447
Julian B. Hyman, Frederick H. Epstein, A study of the correlation between roentgenographic and post-mortem calcification of the aorta American Heart Journal. ,vol. 48, pp. 540- 543 ,(1954) , 10.1016/0002-8703(54)90119-2
Douglas A. Eggen, RELATIONSHIP OF CALCIFIED LESIONS TO CLINICALLY SIGNIFICANT ATHEROSCLEROTIC LESIONS Annals of the New York Academy of Sciences. ,vol. 149, pp. 752- 767 ,(1968) , 10.1111/J.1749-6632.1968.TB53833.X
Katti Fischer-Dzoga, Robert W. Wissler, Dragoslava Vesselinovitch, The effect of estradiol on the proliferation of rabbit aortic medial tissue culture cells induced by hyperlipemic serum Experimental and Molecular Pathology. ,vol. 39, pp. 355- 363 ,(1983) , 10.1016/0014-4800(83)90064-3
JOHN H. WUEST, THOMAS J. DRY, JESSE E. EDWARDS, The Degree of Coronary Atherosclerosis in Bilaterally Oophorectomized Women Circulation. ,vol. 7, pp. 801- 809 ,(1953) , 10.1161/01.CIR.7.6.801
DONNA DAY BAIRD, HERMAN A. TYROLER, GERARDO HEISS, LLOYD E. CHAMBLESS, CURTIS G. HAMES, Menopausal change in serum cholesterol. Black/white differences in Evans County, Georgia. American Journal of Epidemiology. ,vol. 122, pp. 982- 993 ,(1985) , 10.1093/OXFORDJOURNALS.AJE.A114202
ARTHUR U. RIVIN, SIM P. DIMITROFF, The Incidence and Severity of Atherosclerosis in Estrogen-Treated Males, and in Females with a Hypoestrogenic or a Hyperestrogenic State Circulation. ,vol. 9, pp. 533- 539 ,(1954) , 10.1161/01.CIR.9.4.533
James J Schlesselman, Case-Control Studies: Design, Conduct, Analysis ,(1982)
Graham A. Colditz, Walter C. Willett, Meir J. Stampfer, Bernard Rosner, Frank E. Speizer, Charles H. Hennekens, Menopause and the Risk of Coronary Heart Disease in Women New England Journal of Medicine. ,vol. 316, pp. 1105- 1110 ,(1987) , 10.1056/NEJM198704303161801