Gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

摘要: The gut is similar to an endocrine organ, and produces several hormones substances with endocrine, paracrine, autocrine neurocrine effects. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are derived from cells, they can occur anywhere along the gut. In GEP-NETs, normal physiological regulations of lost, released autonomously. Although majority GEP-NETs sporadic, also be part familial syndromes such as multiple neoplasia type 1 (MEN1) syndrome, von-Hippel-Lindau disease, tuberous sclerosis neurofibromatosis 1. rare, incidence 2.5-5 cases per 100,000. Due increased availability advanced endoscopic radiological imaging, diagnosis benign incidentally identified lesions has over past decades. Except for nonfunctioning extensive release by tumor into circulation leads diverse clinical manifestations. Hormones peptides [chromogranin, neurotensin, pancreatic polypeptide (PP), or neuron-specific enolase] frequently ectopically nonfunctional but these do not cause distinct syndromes. recent years, there have been significant advances in treatment tumors. this review, features different types well aspects their medical management will discussed.