Clonal expansion accounts for an excess of antimicrobial resistance in Staphylococcus aureus colonising HIV-positive individuals in Lagos, Nigeria.

摘要: Nasal colonisation with Staphylococcus aureus is a risk factor for invasive infection in human immunodeficiency virus (HIV)-positive individuals. This study aimed to characterise colonising S. from regions high HIV prevalence. Single nasal swabs were taken total of 374 HIV-positive and 370 healthy Overall, 202 carriers detected. Compared individuals, subjects more likely be (33% vs. 21%; P=0.0001). Isolates individuals often resistant meticillin (16% 8%; P=0.13), chloramphenicol (47% 16%; P<0.0001), sulfamethoxazole/trimethoprim (SXT) (90% 55%; P<0.0001) ciprofloxacin (18% 0%; P<0.0001). Strains belonging the spa clonal complexes 3772/ST25 064/ST8 significantly isolated exhibited greater resistance ciprofloxacin, SXT (spa-CC 3772) or 064), respectively. Panton-Valentine leukocidin gene content was overall equally distributed between isolates 30%). Genotypic characteristics similar those reported cause Nigeria. The pandemic contributes evolution antimicrobial aureus. Measures contain Nigeria must target groups such as