Controlled release pharmaceutical compositions for prolonged effect

摘要: Layered pharmaceutical composition suitable for oral use in the treatment of diseases where absorption takes place over a large part gastrointestinal tract. The comprising A) solid inner layer i) an active substance, and ii) one or more disintegrants/exploding agents, effervescent agents mixture thereof. being sandwiched between two outer layers B1) B2), each iii) substantially water soluble and/or crystalline polymer polymers, polyglycol form a) homopolymer having MW at least about 100,000 daltons, b) copolymer 2,000 thereof, iv) which is same as said A), A different from B, layered coated with coating C) that has opening exposing surface layer, insoluble impermeable to fluids polymer, cylindrical optionally tapered ends, wherein ratio area end cylinder length range 0.02 45 mm.