Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking of protecting groups in peptide synthesis

作者: Daniel A. Pearson , Mary Blanchette , Mary Lou Baker , Cathy A. Guindon

DOI: 10.1016/S0040-4039(00)99113-5

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摘要: Abstract Triethylsilane was used as a scavenging agent in peptide synthesis for the removal of protecting groups with TFA. The efficiency ability compared anisole and ethanedithiol kinetic experiment. It also found that triethylsilane/TFA reduces indole ring tryptophan.

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