Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines
作者： Robin S. Bon , Chongen Hong , Marinus J. Bouma , Rob F. Schmitz , Frans J. J. de Kanter
DOI: 10.1021/OL035521G
关键词:
摘要: [reaction: see text] The three-component condensation between an amine, aldehyde, and alpha-acidic isocyanide efficiently provides substituted 2-imidazolines in a one-pot reaction under mild conditions.
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Pierre Cristau, Jean-Pierre Vors, Jieping Zhu, A Rapid Access to Biaryl Ether Containing Macrocycles by Pairwise Use of Ugi 4CR and Intramolecular SNAr-Based Cycloetherification Organic Letters. ,vol. 3, pp. 4079- 4082 ,(2001) , 10.1021/OL0168420
Helena Bradley, Geraldine Fitzpatrick, W. Kenneth Glass, Horst Kunz, Paul V. Murphy, Application of Ugi reactions in synthesis of divalent neoglycoconjugates: evidence that the sugars are presented in restricted conformation. Organic Letters. ,vol. 3, pp. 2629- 2632 ,(2001) , 10.1021/OL016294Q
Rolf Meyer, Ulrich Schöllkopf, Peter Böhme, Synthesen mit α‐metallierten Isocyaniden, XXXIX. 2‐Imidazoline aus α‐metallierten Isocyaniden und Schiff‐Basen; 1,2‐Diamine und 2,3‐Diaminoalkansäuren European Journal of Organic Chemistry. ,vol. 1977, pp. 1183- 1193 ,(1977) , 10.1002/JLAC.197719770715
Ronald Gust, Roland Keilitz, Kathrin Schmidt, Investigations of new lead structures for the design of selective estrogen receptor modulators. Journal of Medicinal Chemistry. ,vol. 44, pp. 1963- 1970 ,(2001) , 10.1021/JM001131D
Hyunsoo Han, Juyoung Yoon, Kim D. Janda, An Efficient Asymmetric Route to 2,3-Diaminobutanoic Acids Journal of Organic Chemistry. ,vol. 63, pp. 2045- 2048 ,(1998) , 10.1021/JO9720391
Hugues Bienaymé, Chris Hulme, Gilles Oddon, Philippe Schmitt, Maximizing Synthetic Efficiency: Multi-Component Transformations Lead the Way Chemistry - A European Journal. ,vol. 6, pp. 3321- 3329 ,(2000) , 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO;2-A
Stefan Lehnhoff, Matthias Goebel, Rosa Maria Karl, Roland Klösel, Ivar Ugi, Stereoselektive Synthesen von Peptidderivaten mit 2‐Acetamido‐3,4,6‐tri‐O‐acetyl‐1‐amino‐2‐desoxy‐β‐D‐glucopyranose durch Vierkomponentenkondensation Angewandte Chemie. ,vol. 107, pp. 1208- 1211 ,(1995) , 10.1002/ANGE.19951071017
Albert M. Van Leusen, Jurjen Wildeman, Otto H. Oldenziel, Chemistry of sulfonylmethyl isocyanides. 12. Base-induced cycloaddition of sulfonylmethyl isocyanides to carbon,nitrogen double bonds. Synthesis of 1,5-disubstituted and 1,4,5-trisubstituted imidazoles from aldimines and imidoyl chlorides Journal of Organic Chemistry. ,vol. 42, pp. 1153- 1159 ,(1977) , 10.1021/JO00427A012
Robert W. Armstrong, Andrew P. Combs, Paul A. Tempest, S. David Brown, Thomas A. Keating, Multiple-Component Condensation Strategies for Combinatorial Library Synthesis Accounts of Chemical Research. ,vol. 29, pp. 123- 131 ,(1996) , 10.1021/AR9502083
Francesco Gentili, Pascal Bousquet, Livio Brasili, Monique Dontenwill, Josiane Feldman, Francesca Ghelfi, Mario Giannella, Alessandro Piergentili, Wilma Quaglia, Maria Pigini, Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. Journal of Medicinal Chemistry. ,vol. 46, pp. 2169- 2176 ,(2003) , 10.1021/JM021113R