Revisiting the role of TRAIL/TRAIL-R in cancer biology and therapy.
作者： Deepika Singh , Mallika Tewari , Sunita Singh , Gopeshwar Narayan
关键词:
摘要: TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily, can induce apoptosis in cancer cells, sparing normal cells when bound to its associated death receptors (DR4/DR5). This unique mechanism makes TRAIL potential anticancer therapeutic agent. However, clinical trials recombinant protein and receptor agonist monoclonal antibodies have shown disappointing results due short half-life, poor pharmacokinetics resistance cells. review summarizes TRAIL-induced apoptotic survival pathways as well mechanisms leading resistance. Recent development methods overcome cell apoptosis, such modification, combination therapy TRAIL-based gene therapy, appear promising. We also discuss challenges opportunities therapies for treatment human cancers.
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