Oral appliance therapy reduces blood pressure in obstructive sleep apnea: A randomized, controlled trial

摘要: STUDY OBJECTIVE To investigate the short-term effect (4 weeks) of oral appliance therapy for obstructive sleep apnea on blood pressure. DESIGN Randomized, controlled, crossover trial. SETTING Multidisciplinary disorders clinic in a university teaching hospital. PATIENTS Sixty-one patients diagnosed with polysomnography (apnea hypopnea index > or = 10 per hour and at least 2 following symptoms--daytime sleepiness, snoring, witnessed apneas, fragmented sleep; age 20 years; minimum mandibular protrusion 3 mm). INTERVENTION A advancement splint (MAS) control 4 weeks each. MEASUREMENTS AND RESULTS Polysomnography 24-hour ambulatory pressure monitoring were carried out baseline each 4-week intervention period. Patients showed 50% reduction mean MAS compared significant improvement both oxygen saturation arousal index. There was (+/- SEM) diastolic (1.8 +/- 0.5 mmHg) (P .001) but not systolic Awake blood-pressure variables reduced by an estimated 3.3 1.1 mmHg .003) 3.4 0.9 < .0001). no difference measured asleep. CONCLUSION Oral over results pressure, similar to that reported continuous positive airway therapy.