Ruminant Fatty Acids and Prostate Cancer Risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

摘要: Consumption of high fat animal products is a characteristic feature Western diets, which have been consistently linked with elevated risks prostate cancer. In order to elucidate specific fatty acids may contribute this association, we measured circulating concentrations myristic (C14:0), pentadecanoic (C15:0), palmitic (C16:0), heptadecanoic (C17:0), vaccenic (C18:1n-7), and alpha-linolenic (C18:3n-3) - all are present in ruminant meat and/or dairy nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Prediagnostic blood samples from 300 cancer cases controls matched on age date serum draw were analyzed for aforementioned by gas chromatography-mass spectrometry. There was positive association between acid overall risk, notable threshold effect (for increasing quartiles, odds ratios 95% confidence intervals = 1.0 (referent), 1.65 (1.02–2.67), 1.96 (1.22–3.14), 1.57 (0.97–2.54); p trend 0.15). This stronger among men low baseline levels beta-carotene vitamin E. The other unrelated risk. Our findings indicate that higher predominant omega-3 diets associated cancer, particularly subgroups antioxidant levels. This abstract one 20 highest scoring abstracts those submitted presentation at 36th Annual ASPO meeting held March 4–6, 2012, Washington, DC.