Correlations between topological resonance energy of methyl-substituted benz[c]acridines, benzo[a]phenothiazines and chrysenes, and their carcinogenic or antitumor activities

摘要: In oder to clarify the effects of methyl substitution on carcinogenic activity, each resonance energy (RE) benz[c]acridines, benzo[a]phenothiazines, chrysene, and their derivatives was calculated by Aihara's TRE theory. Some correlations seem exist between values per π-electron for cationic species - with lack atom having highest approximate superdelocalizability (Sr' (E) ) from parents skeleton activity.