Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor

摘要: A method for prophylaxis of treatment an animal systemic hypotension induced by internal nitrogen oxide production. The involves administering a therapeutically effective amount certain arginine derivatives to inhibit formation from arginine. Preferaby NG -substituted or NG,NG -disubstituted (having at least one hydrogen on terminal guanidino amino group replaced another atomic species) is administered possibly developing already having hypotension. are preferably the L configuration and include pharmaceutically acceptable addition salts. Prophylaxis in patient which has been chemotherapeutic with biologic response modifiers such as tumor necrosis factor interleukin-2 may be accomplished. Treatment endotoxin, i.e., septic shock also accomplished derivatives.