Effect of oxide layer modification of CoCr stent alloys on blood activation and endothelial behavior.

摘要: CoCr alloys, in particular MP35N and L605, are extensively used biomedical implants, for example coronary stents. In practice, these alloys present a moderately hydrophobic surface which leads to significant platelet adhesion consequently risk of early thrombosis or in-stent restenosis. Surface modification implants is known alter their biological performances. this study we focused on the alteration vitro responses human cells contacting surfaces with engineered oxide layers. XPS analysis was performed determine composition layer differently treated while bulk properties were not modified. An extensive characterization looking at roughness, wettability charge. After static exposure blood, strongly reduced increased polymorphonuclear neutrophil observed versus untreated surfaces. Comparisons samples provide evidence being an important player adhesion, although multiple factors including chemistry charge might control adhesion. The shown be equally suitable endothelial cell proliferation. We herein novel approach steer alloys. By adjusting composition, substrates generated growth same time show altered (reduced) blood contact activation. Such treatments expected lead stents highly reproducible quality minimal thrombogenicity restenosis, maintaining rapid re-endothelialization after angioplasty. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2014.