Pathogenesis of Myocardial Injury and Cell Death in Myocarditis: Its Relation to the Fas/Fas Ligand Pathway

摘要: The Fas/APO-1(CD95) cell surface receptor binds to the Fas ligand, leading apoptotic death under a variety of pathological conditions. In viral myocarditis, perforin-based mechanism involving killer cells is known play role in necrotic myocardial injury. However, little about myocarditis. Serum levels soluble form and ligand were much higher patients with myocarditis than other cardiac patients. There was positive correlation between sIL-2R sFas group, sFasligand increased severity heart failure, as defined by New York Heart Association functional class. Cardiac tissues from rats autoimmune showed situ DNA fragments laddering formation TUNEL assay, biological hallmark apoptosis, some cardiomyocytes infiltrating lymphocytes. expression up-regulated mRNA protein expressed CD4+ T cells. Coexpression observed Furthermore, when cultured neonatal exposed presence actinomycin D, underwent death, demonstrated electron microscopy, flow cytometry, assay. These results suggest that portion lymphocytes are subjected possibly due cell-mediated cytotoxicity, which modulated Fas/Fas pathway