Radiotherapy in DCIS, an underestimated benefit?

摘要: Often considered an "indolent" disease for which a treatment de-escalation is advocated, ductal carcinoma in situ (DCIS) of the breast has been recently shown to be associated with significant increase long-term mortality case invasive local recurrence (LR). The publication data from four randomised trials did not prevent continuation debates about pros and cons postoperative radiation therapy (PORT) optimal DCIS management. Actually only partial answers regarding impact PORT on control had brought by these among others due differences pathological assessment controlled studies. A biologically heterogeneous disease, characterised large variation clinical behaviour, hampers identification those patients whom might as overtreatment. At light most recent biological studies, this review tries identify accurately LR risks both tumour- patient-related factors analyse treatment-related parameters impacting significantly patient outcome.