The Significance of Epithelial-to-Mesenchymal Transition for Circulating Tumor Cells
作者： Alexandra Kölbl , Udo Jeschke , Ulrich Andergassen
DOI: 10.3390/IJMS17081308
关键词:
摘要: Epithelial to mesenchymal transition (EMT) is a process involved in embryonic development, but it also plays a role in remote metastasis formation in tumor diseases. During this process cells lose their epithelial features and adopt characteristics of mesenchymal cells. Thereby single tumor cells, which dissolve from the primary tumor, are enabled to invade the blood vessels and travel throughout the body as so called “circulating tumor cells”(CTCs). After leaving the blood stream the reverse process of EMT, the mesenchymal to epithelial …
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