Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes in oropharyngeal cancer stratified by human papillomavirus status.

摘要: BACKGROUND The objective of this study was to investigate the prognostic value pretreatment circulating neutrophil count (CNC), monocyte (CMC), and lymphocyte (CLC) in human papillomavirus (HPV)-related (HPV+) HPV-unrelated (HPV-) oropharyngeal cancer (OPC). METHODS All p16-confirmed HPV+ HPV- OPC cases treated with chemoradiotherapy from 2000 2010 were included. Overall survival (OS) recurrence-free (RFS) compared for high low CNCs, CMCs, CLCs (dichotomized by median values). A multivariate analysis (MVA) confirmed their tumors, respectively. RESULTS Five hundred ten 192 cohort had lower CNC CMC values but a CLC similar that patients (P < .01). follow-up 4.8 years. In cohort, or correlated reduced OS RFS comparison < .01 all), no difference evident = .30) = .10) CLC. MVA higher independently predicted (hazard ratio [HR] CNC, 1.14, P < .01; HR CMC, 2.95, < .01) (HR 1.11, 3.39, < .01), whereas associated (HR, 0.66, = .03) marginally 0.80, = .08). not predictive = .16, = .86, = .14) = .61, = .59, = .62). CONCLUSIONS This relatively large demonstrates predict inferior RFS, predicts better patients. association apparent