Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain.
作者： T.A Slotkin , K.E Pinkerton , J.T Auman , D Qiao , F.J Seidler
DOI: 10.1016/S0165-3806(02)00281-X
关键词:
摘要: In humans, perinatal exposure to environmental tobacco smoke (ETS) is associated with neurobehavioral deficits. the current study, we exposed Rhesus monkeys ETS in late gestation and early neonatal period, examined changes neurotransmitter receptors brainstem caudal portion of cerebral cortex. Nicotinic acetylcholine were markedly upregulated effect was selective that there no m2-muscarinic or β-adrenergic receptors. receptor upregulation indicative chronic cell stimulation by nicotine, a hallmark nicotine-induced neuroteratogenesis. These results indicate exposes fetus neonate quantities nicotine are sufficient alter brain development.
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