Carbon-carbon bond cleavage by P450 systems

摘要: The cytochromes P450 have long been recognized as powerful antioxidants capable of catalysing a wide variety substrate transformations. These features are perhaps nowhere more evident than in their catalysis C-C bong cleavage reactions. Some these reactions relatively simple, occuring one mechanistic step with loss single, activated carbon whilst others much dramatic, involving multiple oxidative transformations and skeletal rearrangement and/or fragmentation the substrate. Almost counter intuitively, usually associated elaborate biosynthetic pathways that build up complex secondary metabolites significant biological activities. They classified here according to functional group(s) is (are) adjacent site bond cleavage, even if moieties introduced by during course multi-step transformation. Excluded from this discussion substrates specifically designed undergo probes, such cyclopropyl containing compounds.