Motoneuron death in normal and spinal muscular atrophy-affected human fetuses.
作者： Anna Fidziańska , Janina Rafalowska
DOI: 10.1007/S00401-002-0566-0
关键词:
摘要: The onset and sequence of motoneuron death in the lumbar part spinal cord seven control five affected fetuses carrying deletion exon 7 SMN gene were studied by light electron microscopy. Naturally occurring was detected between 8 13 weeks gestation. In prolonged also observed at 16 20 addition, motoneurons displayed nuclear abnormalities as early gestation changes progressed developed can be considered first signs degeneration.
springer.com
sci-hub.se 参考文章(15)
A.H. Wyllie, J.F.R. Kerr, A.R. Currie, Cell death : the significance of apoptosis International Review of Cytology-a Survey of Cell Biology. ,vol. 68, pp. 251- 306 ,(1980) , 10.1016/S0074-7696(08)62312-8
Suzie Lefebvre, Philippe Burlet, Qing Liu, Solange Bertrandy, Olivier Clermont, Arnold Munnich, Gideon Dreyfuss, Judith Melki, Correlation between severity and SMN protein level in spinal muscular atrophy. Nature Genetics. ,vol. 16, pp. 265- 269 ,(1997) , 10.1038/NG0797-265
Kathryn J. Jones, Donald W. Pfaff, Bruce S. McEwen, Early estrogen-induced nuclear changes in rat hypothalamic ventromedial neurons: an ultrastructural and morphometric analysis. The Journal of Comparative Neurology. ,vol. 239, pp. 255- 266 ,(1985) , 10.1002/CNE.902390302
M. Lafarga, M.T. Berciano, F.J. Martinez-Guijarro, M.A. Andres, B. Mellström, C. Lopez-Garcia, J.R. Naranjo, Fos-like expression and nuclear size in osmotically stimulated supraoptic nucleus neurons. Neuroscience. ,vol. 50, pp. 867- 875 ,(1992) , 10.1016/0306-4522(92)90210-S
J F R Kerr, A H Wyllie, A R Currie, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer. ,vol. 26, pp. 239- 257 ,(1972) , 10.1038/BJC.1972.33
ANNA FIDZIAŃSKA, HANS H. GOEBEL, IRENE WARLO, Acute infantile spinal muscular atrophy. Muscle apoptosis as a proposed pathogenetic mechanism Brain. ,vol. 113, pp. 433- 445 ,(1990) , 10.1093/BRAIN/113.2.433
David L Vaux, Stanley J Korsmeyer, CELL DEATH IN DEVELOPMENT Cell. ,vol. 96, pp. 245- 254 ,(1999) , 10.1016/S0092-8674(00)80564-4
Anthony T. Yachnis, Mark A. Giovanini, Thomas A. Eskin, Paul J. Reier, Douglas K. Anderson, Developmental patterns of bcl-2 and bcl-x polypeptide expression in the human spinal cord Experimental Neurology. ,vol. 150, pp. 82- 97 ,(1998) , 10.1006/EXNR.1997.6746
M. C. Prestige, Evidence that at least some of the motor nerve cells that die during development have first made peripheral connections. The Journal of Comparative Neurology. ,vol. 170, pp. 123- 133 ,(1976) , 10.1002/CNE.901700109
P. Burlet, C. Huber, S. Bertrandy, M. A. Ludosky, I. Zwaenepoel, O. Clermont, J. Roume, A. L. Delezoide, J. Cartaud, A. Munnich, S. Lefebvre, The distribution of SMN protein complex in human fetal tissues and its alteration in spinal muscular atrophy Human Molecular Genetics. ,vol. 7, pp. 1927- 1933 ,(1998) , 10.1093/HMG/7.12.1927