A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

作者: Michele Cargill , Steven J. Schrodi , Monica Chang , Veronica E. Garcia , Rhonda Brandon

DOI: 10.1086/511051

关键词:

摘要: … how the IL12B and IL23R genes influence an individual’s risk of psoriasis, we assessed the impact of diplotypes at each locus independently and then jointly on psoriasis risk. Of the 10 …

参考文章(76)
A M Valdes, G Thomson, Detecting disease-predisposing variants: the haplotype method. American Journal of Human Genetics. ,vol. 60, pp. 703- 716 ,(1997)
Mary K. Kuhner, Johnny Ludvigsson, Wendy P. Robinson, Ingeborg Deschamps, Bertil Lindblom, Edith Schober, Glenys Thomson, Sharon Joe, Jose Barbosa, Jukka Partanen, Michael J. MacDonald, Brian D. Tait, Jerome L. Gottschall, Wolfgang R. Mayr, Stephen S. Rich, Nadir R. Farid, Christine Thompson, Jörg Bertrams, Max P. Baur, Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of caucasians with insulin-dependent diabetes mellitus American Journal of Human Genetics. ,vol. 43, pp. 799- 816 ,(1988)
Norman E. Breslow, N. E. Day, The analysis of case-control studies International Agency for Research on Cancer. ,(1980)
Steve Rozen, Helen Skaletsky, Primer3 on the WWW for general users and for biologist programmers. Methods of Molecular Biology. ,vol. 132, pp. 365- 386 ,(2000) , 10.1385/1-59259-192-2:365
Grant Morahan, Dexing Huang, Susie I. Ymer, Michael R. Cancilla, Katrina Stephen, Preeti Dabadghao, George Werther, Brian D. Tait, Leonard C. Harrison, Peter G. Colman, Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele Nature Genetics. ,vol. 27, pp. 218- 221 ,(2001) , 10.1038/84872
Philippa Marrack, John Kappler, Brian L. Kotzin, Autoimmune disease: why and where it occurs Nature Medicine. ,vol. 7, pp. 899- 905 ,(2001) , 10.1038/90935
Sir Ronald Aylmer Fisher, Statistical Methods for Research Workers ,(1925)
Amy Wanstrat, Edward Wakeland, The genetics of complex autoimmune diseases: non-MHC susceptibility genes. Nature Immunology. ,vol. 2, pp. 802- 809 ,(2001) , 10.1038/NI0901-802
Gamze Piskin, Regien M. R. Sylva-Steenland, Jan D. Bos, Marcel B. M. Teunissen, In Vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin The Journal of Immunology. ,vol. 176, pp. 1908- 1915 ,(2006) , 10.4049/JIMMUNOL.176.3.1908