Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer.

作者: Ron H J Mathijssen , Stijn L W Koolen , Ruben A G van Eerden

DOI: 10.2147/IJN.S272529

关键词:

摘要: Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety malignancies. Nevertheless, large proportion patients do not benefit from their treatment while they suffer from severe adverse events related to solvent or the active compound. Cremophor EL and polysorbate 80 free formulations, conjugates, oral formulations different types drug delivery systems some examples several attempts improve with taxanes. In this review article, we discuss recent clinical developments nanomediated for of cancer. Targeting mechanisms characteristics most commonly taxane-containing in clinical setting will be discussed review.

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