The modulation of cerebral cortex and subcortical nuclei on NRM and their role in acupuncture analgesia

摘要: The vast research have demonstrated that the acupuncture analgesia is effected through a physiological mechanism brought about by nervous system, particularly central system. We combined effects and theory of channels collaterals with new advance pain neurophysiology, centred attention on nucleus raphe magnus (NRM), one origins important descending inhibitory pathways intrinsic analgesic systems in brain. unit discharges NRM neurons their nociceptors/ph responses were recorded extracellularly glass microelectrode at 1495 634 wastar rats. modulation cerebral cortex, head N. caudatum (NCa), Accumbens (N. Ac), N lateral habenular (NHa) Periaquaeductal gray matter (PAG) role studied locational stimulation, lesion microinjection. result as follows: 1. most could respond to noxious stimulation tail tip increasing or decreasing firing rate. Electroacupuncture (EA) "Zusanli" activate neuron, discharges, inhibit nociceptive responses, producing analgesia. 2. activity neuron was modulated PAG, NAc, NCa. Stimulation them can NRM, rate, induce When microinjection naloxone made NAc NCa, EA be weakened lost, even might increased. It suggest nuclei participated endogenous opiate like substance, playing an role. also indicated electroacupuncture used patients some pathological changes should careful avoid making feel more painful. 3. Somatosensory area II (Sm II) cortex reduced after Sm II. inhibited further achieved via NHa closely related limbic-midbrain dorsal fasciculus (DLF) level spinal cord. 4. sensorimotor (SM) seems not necessary structure for Either hindlimb areas larger range bilateral SM resected, obviously influenced. somatosensory I I) neurons. modulate mediation NCa extrapyramidal system enhancing directly pyramidal cord, But information so it antagonism Thus when patient's emotion very physical exercise strong, would decreased. Therefore, order guarantee effects, take rest calm down before electroacupuncture. contrary action between may mechanisms full changeful.