Antitumor effect of a mycotoxin: rubratoxin B.

摘要: The antitumor effect of rubratoxin B, a mycotoxin, has been studied. Yoshida ascites sarcoma cells, in vitro contact for 30 min with the drug and injected immediately afterwards into young rats by intraperitoneal route, produced survival 80% animals doubling median time developing neoplasia. In vivo administration route 24 h after implantation tumor cells determined prolongation time; supplied other routes both against T8 Guerin it was ineffective. differences between results can be explained rapid neutralization on behalf organism’s enzymes or being bound to proteins peritoneal unlike cells.