A 3'-untranslated region variant (rs2289046) of insulin receptor substrate 2 gene is associated with susceptibility to nonalcoholic fatty liver disease.

摘要: Purpose Nonalcoholic fatty liver disease (NAFLD) is an increasing global health concern defined by excessive hepatic fat content in the absence of alcohol consumption. Regarding key role insulin and resistance NAFLD, we investigated whether receptor substrate 1 (IRS1) 2 (IRS2) gene variants were associated with NAFLD risk. Methods In this case-control study, 305 subjects including 151 cases biopsy-proven 154 controls enrolled. All genotyped for IRS1 (rs1801278) IRS2 (rs2289046) using PCR-RFLP method. Results Our findings showed that rs2289046 "GG+AG" genotype compared "AA" to be a marker decreased susceptibility difference remained significant even after adjustment confounding factors age, BMI, sex, smoking status, systolic blood pressure, diastolic pressure (P=0.014; OR=0.50, 95%CI= 0.29-0.87). Furthermore, "G" allele was significantly underrepresented than (P=0.026 ; OR=0.62, 95%CI=0.41-0.94). However, no found rs1801278 variant. Conclusions This study suggests, first time, variant may play susceptibility. Nevertheless, observation warrants further investigations other populations.