The secreted Frizzled-Related Protein 2 modulates cell fate and the Wnt pathway in the murine intestinal epithelium.

作者: Seham Skah , Julien Nadjar , Maria Sirakov , Michelina Plateroti

DOI: 10.1016/J.YEXCR.2014.10.014

关键词:

摘要: Abstract The secreted Frizzled-Related Proteins (sFRPs) are generally considered antagonistic to Wnt signaling. However, several studies have described their synergy and/or activation of this pathway. Our own data indicated that in the intestinal epithelium, thyroid hormone induced-expression sFRP2 stabilizes β-catenin, leading induction Wnt. aim work was investigate role epithelium homeostasis and its specific effect on canonical In wild type animals we observed a restricted pattern protein expression at level crypts. Interestingly, sFRP2−/− mice displayed increased apoptosis within crypts together with defect cell migration. Because altered proportion lineage-specific committed progenitors, also showed decrease absorptive differentiation counterbalanced by an increase secretory differentiation. Regarding action pathway, lack sFRP2−/−/TopGal vivo reduced activity. This positive further confirmed vitro studies. conclusion, accordance profile, contributes physiology epithelial crypt progenitors controlling apoptosis, fate decisions

参考文章(37)
Kunitoshi Shigeyasu, Hiroyuki Nishie, Takeshi Nagasaka, Masanori Takeda, Satoshi Mizobuchi, Toshiyoshi Fujiwara, Eiji Yamada, Yoshiko Mori, Tatsuya Morikawa, Sun Dong-Sheng, Tetsuhiro Oka, Expansion of CpG methylation in the SFRP2 promoter region during colorectal tumorigenesis. Acta Medica Okayama. ,vol. 65, pp. 169- 177 ,(2011) , 10.18926/AMO/46628
Jan Jensen, Erna Engholm Pedersen, Philip Galante, Jacob Hald, R. Scott Heller, Makoto Ishibashi, Ryoichiro Kageyama, Francois Guillemot, Palle Serup, Ole D. Madsen, Control of endodermal endocrine development by Hes-1. Nature Genetics. ,vol. 24, pp. 36- 44 ,(2000) , 10.1038/71657
Taeko K. Noah, Bridgitte Donahue, Noah F. Shroyer, Intestinal development and differentiation Experimental Cell Research. ,vol. 317, pp. 2702- 2710 ,(2011) , 10.1016/J.YEXCR.2011.09.006
Freddy Radtke, Hans Clevers, Self-Renewal and Cancer of the Gut: Two Sides of a Coin Science. ,vol. 307, pp. 1904- 1909 ,(2005) , 10.1126/SCIENCE.1104815
Jeffrey I Gordon, Thaddeus S Stappenbeck, Melissa H Wong, Jennifer R Saam, Indira U Mysorekar, Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium Current Opinion in Cell Biology. ,vol. 10, pp. 702- 709 ,(1998) , 10.1016/S0955-0674(98)80110-5
H. S. Melkonyan, W. C. Chang, J. P. Shapiro, M. Mahadevappa, P. A. Fitzpatrick, M. C. Kiefer, L. D. Tomei, S. R. Umansky, SARPs: a family of secreted apoptosis-related proteins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 13636- 13641 ,(1997) , 10.1073/PNAS.94.25.13636
M. Mirotsou, Z. Zhang, A. Deb, L. Zhang, M. Gnecchi, N. Noiseux, H. Mu, A. Pachori, V. Dzau, Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 1643- 1648 ,(2007) , 10.1073/PNAS.0610024104