作者: Seham Skah , Julien Nadjar , Maria Sirakov , Michelina Plateroti
DOI: 10.1016/J.YEXCR.2014.10.014
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摘要: Abstract The secreted Frizzled-Related Proteins (sFRPs) are generally considered antagonistic to Wnt signaling. However, several studies have described their synergy and/or activation of this pathway. Our own data indicated that in the intestinal epithelium, thyroid hormone induced-expression sFRP2 stabilizes β-catenin, leading induction Wnt. aim work was investigate role epithelium homeostasis and its specific effect on canonical In wild type animals we observed a restricted pattern protein expression at level crypts. Interestingly, sFRP2−/− mice displayed increased apoptosis within crypts together with defect cell migration. Because altered proportion lineage-specific committed progenitors, also showed decrease absorptive differentiation counterbalanced by an increase secretory differentiation. Regarding action pathway, lack sFRP2−/−/TopGal vivo reduced activity. This positive further confirmed vitro studies. conclusion, accordance profile, contributes physiology epithelial crypt progenitors controlling apoptosis, fate decisions