Development of a novel prolonged-release nicotine transdermal patch.
作者： Soodabeh Davaran , Mohammad R. Rashidi , Reza Khandaghi , Mahdi Hashemi
DOI: 10.1016/J.PHRS.2004.08.006
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摘要: Abstract A transdermal patch for delivering nicotine periods of 12–48 h was designed. An inclusion complex formed between the and β-cyclodextrine (β-CD) used in drug depot. The usefulness a specially cross-linked polyvinyl alcohol (cross-PVA) membrane investigated as rate controlling membrane. influence carbopol polymers, type C-934P C-940 propylene glycol on permeation through rat skin investigated. results indicated maximum flux 42 μg cm −2 h −1 after 48 h from patches made when concentration 15% nicotine-β-CD mole ratio 3:1. These can be fabricated to obtain controlled release, zero order systems.
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sci-hub.se 参考文章(16)
Nancy A Rigotti, Julia H Arnsten, Kathleen M McKool, Kristen M Wood-Reid, Daniel E Singer, Richard C Pasternak, The use of nicotine-replacement therapy by hospitalized smokers. American Journal of Preventive Medicine. ,vol. 17, pp. 255- 259 ,(1999) , 10.1016/S0749-3797(99)00095-1
Bret Berner, Gerard C. Mazzenga, Paul M. Gargiulo, Robert Steffens, A transdermal nicotine system: feasibility studies Journal of Controlled Release. ,vol. 20, pp. 13- 19 ,(1992) , 10.1016/0168-3659(92)90134-D
Randolph W. Parks, Robert E. Becker, Robert F. Rippey, David G. Gilbert, Jane R. Matthews, Esperanza Kabatay, Carter S. Young, Cathy Vohs, Valerie Danz, Patricia Keim, G. Todd Collins, Steven S. Zigler, Paul G. Urycki, Increased regional cerebral glucose metabolism and semantic memory performance in Alzheimer's disease: A pilot double blind transdermal nicotine positron emission tomography study Neuropsychology Review. ,vol. 6, pp. 61- 79 ,(1996) , 10.1007/BF01875368
David J.K. Balfour, Karl O. Fagerström, Pharmacology of nicotine and its therapeutic use in smoking cessation and neurodegenerative disorders Pharmacology & Therapeutics. ,vol. 72, pp. 51- 81 ,(1996) , 10.1016/S0163-7258(96)00099-X
Ramesh Panchagnula, Pramod Sridhar Salve, Narisetty Sunil Thomas, Amit Kumar Jain, Poduri Ramarao, Transdermal delivery of naloxone: effect of water, propylene glycol, ethanol and their binary combinations on permeation through rat skin International Journal of Pharmaceutics. ,vol. 219, pp. 95- 105 ,(2001) , 10.1016/S0378-5173(01)00634-2
Jed E Rose, Frederique M Behm, Eric C Westman, Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking Pharmacology Biochemistry and Behavior. ,vol. 68, pp. 187- 197 ,(2001) , 10.1016/S0091-3057(00)00465-2
Paul A Newhouse, Megan Kelton, Nicotinic systems in central nervous systems disease: degenerative disorders and beyond. Pharmaceutica Acta Helvetiae. ,vol. 74, pp. 91- 101 ,(2000) , 10.1016/S0031-6865(99)00047-3
Derek Lewis, Mário Paulo, Eduardo Faustino, Asçensão Farinha, In vitro comparative studies of transdermal nicotine delivery systems International Journal of Pharmaceutics. ,vol. 148, pp. 177- 189 ,(1997) , 10.1016/S0378-5173(96)04843-0
A. Nordberg, P. Hartvig, A. Lilja, M. Viitanen, K. Amberla, H. Lundqvist, Y. Andersson, J. Ulin, B. Winblad, B. Långström, Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography Journal of Neural Transmission - Parkinson's Disease and Dementia Section. ,vol. 2, pp. 215- 224 ,(1990) , 10.1007/BF02257652
Heidi K. White, E. D. Levin, Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer’s disease Psychopharmacology. ,vol. 143, pp. 158- 165 ,(1999) , 10.1007/S002130050931