Folding and Wrapping Soluble Proteins: Exploring the Molecular Basis of Cooperativity and Aggregation

摘要: Publisher Summary This chapter focuses on the recent advances in understanding of folding soluble proteins, mostly focusing molecular basis co-operativity. Wrapping refers to environmental modulation or protection intra-molecular electrostatic interactions through an exclusion surrounding water that takes place as chain folds onto itself. Thus, a special many-body picture process is shown emerge where not only interacts with itself but also shapes micro-environments stabilize destabilize interactions. Taken together, hydration propensity amide and carbonyl dehydration-induced strengthening their association represent two conflictive tendencies, suggesting there must be crossover point dehydration backbone hydrogen bond. The dehydronic force arises nonpolar group approaches dehydron net effect immobilizing ultimately removing molecules. displacement lowers polarizability microenvironment which, turn, deshields paired charges.