A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer.

作者: Shengyang Qiu , Gianluca Pellino , Francesca Fiorentino , Shahnawaz Rasheed , Ara Darzi

DOI: 10.1155/2017/6456257

关键词:

摘要: Neurotensin (NTS) is a physiologically occurring hormone which affects the function of gastrointestinal (GI) tract. In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in carcinogenesis several cancers. colorectal cancer (CRC), significant body evidence, from vitro and vivo studies, available elucidates molecular biology NTS/NTSR signalling resultant growth CRC cells. There growing clinical data human studies corroborate role plays development CRC. Furthermore, blockade modulation pathways appears to reduce cell cultures animal studies. Lastly, also shows potential being utilised as diagnostic biomarker for cancers well targets functional imaging. We summarise existing evidence understanding NTS

参考文章(65)
Sandra Dupouy, Van Kien Doan, Zherui Wu, Najat Mourra, Jin Liu, Olivier De Wever, Frédérique Penault Llorca, Anne Cayre, Amal Kouchkar, Anne Gompel, Patricia Forgez, Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice Oncotarget. ,vol. 5, pp. 8235- 8251 ,(2014) , 10.18632/ONCOTARGET.1632
Robert Carraway, Susan E. Leeman, The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami Journal of Biological Chemistry. ,vol. 248, pp. 6854- 6861 ,(1973) , 10.1016/S0021-9258(19)43429-7
Nancy G Hernandez-Chan, Michael J Bannon, Carlos E Orozco-Barrios, Lourdes Escobedo, Sergio Zamudio, Fidel De la Cruz, Jose L Gongora-Alfaro, Juan Armendáriz-Borunda, David Reyes-Corona, Armando J Espadas-Alvarez, Yazmin M Flores-Martínez, Jose Ayala-Davila, Maria E Hernandez-Gutierrez, Lenin Pavón, Refugio García-Villegas, Rasajna Nadella, Daniel Martinez-Fong, None, Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson’s disease Journal of Biomedical Science. ,vol. 22, pp. 59- 59 ,(2015) , 10.1186/S12929-015-0166-7
Mohamad Younes, Zherui Wu, Sandra Dupouy, Audrey Mansuet Lupo, Najat Mourra, Takashi Takahashi, Jean François Fléjou, Jean Trédaniel, Jean François Régnard, Diane Damotte, Marco Alifano, Patricia Forgez, Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib. Oncotarget. ,vol. 5, pp. 8252- 8269 ,(2014) , 10.18632/ONCOTARGET.1633
Seiko Kamimae, Eiichiro Yamamoto, Masahiro Kai, Takeshi Niinuma, Hiro-o Yamano, Masanori Nojima, Kennjiro Yoshikawa, Tomoaki Kimura, Ryo Takagi, Eiji Harada, Taku Harada, Reo Maruyama, Yasushi Sasaki, Takashi Tokino, Yasuhisa Shinomura, Tamotsu Sugai, Kohzoh Imai, Hiromu Suzuki, Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors. Oncotarget. ,vol. 6, pp. 29975- 29990 ,(2015) , 10.18632/ONCOTARGET.5034
Rebecca M. Myers, James W. Shearman, Matthew O. Kitching, Antonio Ramos-Montoya, David E. Neal, Steven V. Ley, Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors. ACS Chemical Biology. ,vol. 4, pp. 503- 525 ,(2009) , 10.1021/CB900038E
M Tasuta, H Iishi, M Baba, H Taniguchi, Enhancement by neurotensin of experimental carcinogenesis induced in rat colon by azoxymethane. British Journal of Cancer. ,vol. 62, pp. 368- 371 ,(1990) , 10.1038/BJC.1990.299
Ann E. Allen, Desmond N. Carney, Terry W. Moody, Neurotensin binds with high affinity to small cell lung cancer cells. Peptides. ,vol. 9, pp. 57- 61 ,(1988) , 10.1016/0196-9781(88)90224-0