作者: Shengyang Qiu , Gianluca Pellino , Francesca Fiorentino , Shahnawaz Rasheed , Ara Darzi
DOI: 10.1155/2017/6456257
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摘要: Neurotensin (NTS) is a physiologically occurring hormone which affects the function of gastrointestinal (GI) tract. In recent years, NTS, acting through its cellular receptors (NTSR), has been implicated in carcinogenesis several cancers. colorectal cancer (CRC), significant body evidence, from vitro and vivo studies, available elucidates molecular biology NTS/NTSR signalling resultant growth CRC cells. There growing clinical data human studies corroborate role plays development CRC. Furthermore, blockade modulation pathways appears to reduce cell cultures animal studies. Lastly, also shows potential being utilised as diagnostic biomarker for cancers well targets functional imaging. We summarise existing evidence understanding NTS