The role of eicosanoids in 17α, 20β-dihydroxy-4-pregnen-3-one-induced ovulation and spawning in Danio rerio.
作者： Olivia M. Knight , Glen Van Der Kraak
DOI: 10.1016/J.YGCEN.2014.12.014
关键词:
摘要: This study employed a hormone bioassay to characterize the eicosanoids involved in zebrafish ovulation and spawning, particular prostaglandin (PG) products of cyclooxygenase (COX) metabolism leukotriene (LT) lipoxygenase (LOX) metabolism. Exposure teleost progestogen 17α, 20β-dihydroxy-4-pregnen-3-one (17,20βP) induced ovulation, but not solitary females both spawning male-female pairs. Transcription eicosanoid-synthesizing enzymes cytosolic phospholipase A2 (cPLA(2)) COX-2 increased LTC(4) synthase decreased peri-ovulatory ovaries 17,20βP-exposed fish. Ovarian PGF(2α) levels post-spawning fish, there was no difference LTB(4) or LTC(4). Pre-exposure cPLA(2) LOX inhibitors reduced 17,20βP-induced rates, while COX inhibitor had effect on spawning. Collectively, these findings suggest that eicosanoids, metabolites, mediate zebrafish. metabolites also appear be their role remains undefined.
elsevier.com
sci-hub.se 参考文章(55)
Alex Tsafriri, Ovulation as a Tissue Remodelling Process Advances in Experimental Medicine and Biology. ,vol. 377, pp. 121- 140 ,(1995) , 10.1007/978-1-4899-0952-7_8
Makito Kobayashi, Peter W Sorensen, Norm E Stacey, Hormonal and pheromonal control of spawning behavior in the goldfish Fish Physiology and Biochemistry. ,vol. 26, pp. 71- 84 ,(2002) , 10.1023/A:1023375931734
Reynaldo Patiño, Craig V Sullivan, Ovarian follicle growth, maturation, and ovulation in teleost fish Fish Physiology and Biochemistry. ,vol. 26, pp. 57- 70 ,(2002) , 10.1023/A:1023311613987
John A. McCracken, Prostaglandins and Leukotrienes Humana Press. pp. 93- 111 ,(2005) , 10.1007/978-1-59259-829-8_7
Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman, Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biology. ,vol. 3, pp. 1- 12 ,(2002) , 10.1186/GB-2002-3-7-RESEARCH0034
Shlomo Melmed, P. Michael Conn, Endocrinology : basic and clinical principles Humana Press. ,(1997)
Yoshitaka Nagahama, Masakane Yamashita, Regulation of oocyte maturation in fish. Development Growth & Differentiation. ,vol. 50, pp. 393- 439 ,(2008) , 10.1111/J.1440-169X.2008.01019.X
Christine Pollaschek, Karl M Stuhlmeier, Quinacrine but not chloroquine inhibits PMA induced upregulation of matrix metalloproteinases in leukocytes: quinacrine acts at the transcriptional level through a PLA2-independent mechanism. The Journal of Rheumatology. ,vol. 33, pp. 472- 480 ,(2006)
Amy K. Berndtson, Frederick William Goetz, Priscilla Duman, In vitro ovulation, prostaglandin synthesis, and proteolysis in isolated ovarian components of yellow perch (Perca flavescens): Effects of 17α,20β-dihydroxy-4-pregnen-3-one and phorbol ester General and Comparative Endocrinology. ,vol. 75, pp. 454- 465 ,(1989) , 10.1016/0016-6480(89)90181-0
R. van den Hurk, W.G.E.J. Schoonen, G.A. van Zoelen, J.G.D. Lambert, The biosynthesis of steroid glucuronides in the testis of the zebrafish, Brachydanio rerio, and their pheromonal function as ovulation inducers. General and Comparative Endocrinology. ,vol. 68, pp. 179- 188 ,(1987) , 10.1016/0016-6480(87)90027-X