Melatonin Inhibits Reactive Oxygen Species-Driven Proliferation, Epithelial-Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer.

摘要: Globally, oral cancer is the most common type of head and neck cancers. Melatonin elicits inhibitory effects on cancer; however, biological function melatonin underlying mechanisms remain largely unknown. In this study, we found that impaired proliferation apoptosis resistance cells by inactivating ROS-dependent Akt signaling, involving in downregulation cyclin D1, PCNA, Bcl-2 upregulation Bax. inhibited migration invasion repressing ROS-activated implicating with reduction Snail Vimentin enhancement E-cadherin. Moreover, hampered vasculogenic mimicry through blockage extracellular-regulated protein kinases (ERKs) pathways hypoxia-inducible factor 1α. Consistently, retarded tumorigenesis vivo. Overall, these findings indicated exerts antisurvival, antimotility, antiangiogenesis partly suppressing ROS-reliant or ERK signaling.