Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus

摘要: Middle East respiratory syndrome coronavirus (MERS-CoV) is a new highly pathogenic human coronaviruses that emerged in Jeddah and Saudi Arabia has quickly spread to other countries East, Europe North Africa since 2012. Up 17 December 2014, it infected at least 938 people with fatality rate of about 36% globally. This resulted an urgent need identify antiviral drugs are active against MERS-CoV. The papain-like protease (PL pro ) MERS-CoV represents important target as not only essential for viral maturation, but also antagonizes interferon stimulation the host via its deubiquitination activity. Here, we report discovery two SARS-CoV PL inhibitors,