Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins.

摘要: The study was performed to examine whether indomethacin administered during the initial period of acetic acid-induced gastric ulcer healing affects future recurrence. Gastric ulcers were produced in rats by subserosal injection acid. Indomethacin (1 mg/kg/day, orally) either alone or concomitant with ornoprostil (50µg/kg/day, started on fourth day and continued for 56 days. In whose healed at 90th after production ulcer, endoscopy done every 30 days recurrence ulcer. specimens obtained 10, 30, 60, 90, 240 histology, quantitate height regenerated mucosa, thickness fibrous tissue, degree polymorphonuclear cell infiltration, PAS-positive cells. Cumulative rate significantly higher initially treated than controls. Increased infiltration major histologic abnormality persisting cessation indomethacin. Ornoprostil reversed these abnormalities caused conclusion, administration promoted persistent increased rates, possibly via a prostaglandin-dependent mechanism.