Nucleic Acids: Environmental Chemistry, Structures and Interactions as Revealed by Computational Studies

摘要: A rigorous analysis of results obtained from the recent high-level theoretical calculations and experimental measurements on nucleic acid fragments, especially bases base pairs are reported. It is well-known that environmental factors such as metal cations water molecules essential for proper physiological structure acids. Variation in degree hydration or cation concentration can change (conformation) deoxyribonucleic (DNA). Nucleic endowed with high photostability property attained due to ultrashort excited state lifetimes, which order subpicosecond. The extremely small lifetime, a consequence ultrafast nonradiative deactivation, does not allow enough time photoreaction. show electronic singlet geometries generally nonplanar. geometrical distortion along certain bonds leads conical intersections between ground potential energy surfaces, thus facilitate deactivation. There one more factor fast development new type technology – nanotechnology becomes vital society its well-being. has been speculated airborne nanoparticles may cause allergic reactions lead asbestosis disease upon prolonged exposure. Several investigations have suggested fullerene derivatives induce nucleotide chain cleavage mainly at guanine site DNA. Nanomaterials bind DNA, protein, different receptor sites, travel those might be usually unaccessible. Therefore, toxicological nanomaterials will needed before widespread commerical application.