Brain Tumors Overexpressing Epidermal Growth Factor Receptor An Optical Probe for Noninvasive Molecular Imaging of Orthotopic

作者： Ann-Marie Broome , Richard S. Agnes , Jing Wang

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摘要: We have developed a near-infrared (NIR) probe that targets cells overexpressing the EGF receptor (EGFR) for imaging glioblastoma brain tumors in live subjects. A peptide specific EGFR was modified with various lengths of monodiscrete polyethylene glycol (PEG) units and NIR Cy5.5 fluorescence dye. The lead compound, compound 2, one unit PEG displayed good binding (8.9 mmol/L) cellular uptake vitro. vivo studies shown able to selectively label glioblastoma-derived orthotopic tumors. In image analyses using fluorescence-mediated molecular tomography revealed could distinguish between expressing different levels EGFR. data presented here represent first demonstration differential quantitation animals by targeted device. Mol Cancer Ther; 11(10); 2202–11. 2012 AACR.

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参考文章(29)

Victor J. Hruby, Richard S. Agnes, Chaozhong Cai, Design of peptide agonists. Methods in Enzymology. ,vol. 343, pp. 73- 91 ,(2002) , 10.1016/S0076-6879(02)43128-X

Jihua Hao, Adrian W. R. Serohijos, Gail Newton, Gina Tassone, Zuncai Wang, Dennis C. Sgroi, Nikolay V. Dokholyan, James P. Basilion, Identification and Rational Redesign of Peptide Ligands to CRIP1, A Novel Biomarker for Cancers PLoS Computational Biology. ,vol. 4, pp. e1000138- ,(2008) , 10.1371/JOURNAL.PCBI.1000138

Fernanda I. Staquicini, Michael G. Ozawa, Catherine A. Moya, Wouter H.P. Driessen, E. Magda Barbu, Hiroyuki Nishimori, Suren Soghomonyan, Leo G. Flores, Xiaowen Liang, Vincenzo Paolillo, Mian M. Alauddin, James P. Basilion, Frank B. Furnari, Oliver Bogler, Frederick F. Lang, Kenneth D. Aldape, Gregory N. Fuller, Magnus Höök, Juri G. Gelovani, Richard L. Sidman, Webster K. Cavenee, Renata Pasqualini, Wadih Arap, Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. Journal of Clinical Investigation. ,vol. 121, pp. 161- 173 ,(2011) , 10.1172/JCI44798

Towia A. Libermann, Harris R. Nusbaum, Nissim Razon, Richard Kris, Irit Lax, Hermona Soreq, Nigel Whittle, Michael D. Waterfield, Axel Ullrich, Joseph Schlessinger, Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin Nature. ,vol. 313, pp. 144- 147 ,(1985) , 10.1038/313144A0

Ralph Weissleder, Mikael J. Pittet, Imaging in the era of molecular oncology Nature. ,vol. 452, pp. 580- 589 ,(2008) , 10.1038/NATURE06917

William M. Pardridge, Drug and gene targeting to the brain with molecular trojan horses Nature Reviews Drug Discovery. ,vol. 1, pp. 131- 139 ,(2002) , 10.1038/NRD725

Edward R. Laws, Ian F. Parney, Wei Huang, Fred Anderson, Angel M. Morris, Anthony Asher, Kevin O. Lillehei, Mark Bernstein, Henry Brem, Andrew Sloan, Mitchel S. Berger, Susan Chang, _ _, Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. Journal of Neurosurgery. ,vol. 99, pp. 467- 473 ,(2003) , 10.3171/JNS.2003.99.3.0467

Renata Pasqualini, Erkki Ruoslahti, Organ targeting In vivo using phage display peptide libraries Nature. ,vol. 380, pp. 364- 366 ,(1996) , 10.1038/380364A0

Y. Urano, M. Sakabe, N. Kosaka, M. Ogawa, M. Mitsunaga, D. Asanuma, M. Kamiya, M. R. Young, T. Nagano, P. L. Choyke, H. Kobayashi, Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe Science Translational Medicine. ,vol. 3, ,(2011) , 10.1126/SCITRANSLMED.3002823

10.

Hongki Yoo, Jin Won Kim, Milen Shishkov, Eman Namati, Theodore Morse, Roman Shubochkin, Jason R McCarthy, Vasilis Ntziachristos, Brett E Bouma, Farouc A Jaffer, Guillermo J Tearney, Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo Nature Medicine. ,vol. 17, pp. 1680- 1684 ,(2011) , 10.1038/NM.2555

Brain Tumors Overexpressing Epidermal Growth Factor Receptor An Optical Probe for Noninvasive Molecular Imaging of Orthotopic

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Brain Tumors Overexpressing Epidermal Growth Factor Receptor An Optical Probe for Noninvasive Molecular Imaging of Orthotopic

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