Human Neuroepithelial Cells Express NMDA Receptors

摘要: L-glutamate, an excitatory neurotransmitter, binds to both ionotropic and metabotropic glutamate receptors. In certain parts of the brain BBB contains two normally impermeable barriers: 1) cerebral endothelial barrier 2) epithelial barrier. Human cells express NMDA receptors; however, date, human (neuroepithelial cells) have not been shown receptor message or protein. this study, hypothalamic sections were examined for receptors (NMDAR) expression via immunohistochemistry murine neuroepithelial cell line (V1) NMDAR RT-PCR Western analysis. We found that epithelium protein cultured mouse mRNA receptor. These findings may important consequences responses during excitotoxicity in disease.