Genome-wide association mapping of provitamin A carotenoid content in cassava

摘要: Global efforts are underway to develop staple crops with improved levels of provitamin A carotenoids help combat dietary vitamin deficiency, which is widespread among resource-poor farmers in the developing world. As a crop for more than 500 million people sub-Saharan Africa, cassava (Manihot esculenta Crantz) enriched could have immense nutritional impact. To this effort, genome-wide association study (GWAS) was conducted aim identifying genomic regions controlling variation carotenoid concentration as basis undertaking systematic genetic improvement content. high throughput genotyping-by-sequencing platform used genotype diverse panel 591 genotypes and identified 179,310 single nucleotide polymorphisms (SNPs) distributed across genome. region stretching 1.37 Mb on chromosome 1 four SNPs significantly associated content cassava. survey genome sequence v6.1 positioned these vicinity Manes.01G124200.1 locus, known gene responsible increase accumulation roots. This provides one pioneer insights into practical application GWAS dissecting traits Findings presented herein offer grounds improving through marker-assisted breeding selection.