Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses.

摘要: It has been 40 years since the last influenza pandemic and it is generally considered that another could occur at any time. Recent introductions of A viruses from avian sources into human population have raised concerns these may be a source future strain. Therefore, there need to better understand pathogenicity for mammalian species so we able predict potential such develop improved methods their prevention control. In this review, describe virulence H5 H7 in mouse ferret models. The use models providing exciting new insights contribution virus host responses toward viruses, tropism, transmissibility. Identifying role individual viral gene products mapping molecular determinants influence severity disease observed following infection dependent on reliable animal As continue cause death, pathogenesis studies identify avenues investigation novel preventative therapeutic agents effective event pandemic.