Alcoholic liver injury: pathogenesis and therapy in 2001.

摘要: Much progress has been made in the understanding of pathogenesis alcoholic liver disease, resulting improvement prevention and promising prospects for even more effective treatments. It continues to be important replenish nutritional deficiencies when present but it is crucial recognize that, because alcohol-induced disease process, some requirements change. For instance, methionine, one essential amino acids humans, must activated SAMe but, severe activity corresponding enzyme depressed. Therefore, associated pathology can attenuated by administration SAMe, not methionine. Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which hepatic phosphatidylcholine (PC) synthesis, also depressed therefore calling products reaction. might beneficial add other compounds such therapeutic regiment. Since free radical generation ethanol-induced CYP2E1 plays a key role oxidative stress, inhibitors this have great promise. Several investigated experimentally PPC particularly interesting its innocuity. In view striking negative interaction between injury hepatitis C, an antiviral agent eagerly awaited unlike Interferon, contraindicated alcoholic. Anti-inflammatory agents are required. addition down-regulators cytokines end toxic being considered. Finally, since excess drinking crux issue, anticraving should incorporated any contemplated cocktail, recent results obtained with these as naltrexone acamprosate.