The Role of p73 G4C14-to-A4T14 Polymorphism in the Susceptibility to Cervical Cancer
作者： Rogéria Craveiro , Isabel Bravo , Raquel Catarino , Ana Luisa Teixeira , Hugo Sousa
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摘要: Several reports have suggested the importance of p73 polymorphisms in tumor behavior. We investigated role a gene polymorphism susceptibility to cervical lesions southwestern European population. Peripheral blood samples were obtained from Radiotherapy and Gynaecology Departments Portuguese Institute Oncology (Porto, Portugal), 1998 2002. analyzed cytosine thymine peripheral DNA 176 healthy donors, 38 high-grade squamous intraepithelial (HSIL), 141 patients with primary untreated invasive cancers (ICC), by polymerase chain reaction–restriction fragment length polymorphism. Our results demonstrate twofold increased development HSIL women carrying AT allele (OR=2.39; p=0.022). Further, this association seems be more evident high parity (OR=12.53; p=0.007). This is agreement possible carcinogenesis, namely, human papillomav...
sci-hub.se 参考文章(52)
Jeffrey M. Arbeit, Liang Jin, Gaung Yu Yang, Karen J. Auborn, Da Zhi Chen, Mei Qi, Ann Anderson, Indole-3-Carbinol Prevents Cervical Cancer in Human Papilloma Virus Type 16 (HPV16) Transgenic Mice Cancer Research. ,vol. 59, pp. 3991- 3997 ,(1999)
B M Ryan, R McManus, J S Daly, E Carton, P W N Keeling, J V Reynolds, D Kelleher, A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma. British Journal of Cancer. ,vol. 85, pp. 1499- 1503 ,(2001) , 10.1054/BJOC.2001.2066
Paul F Lambert, Karl Münger, Tiffany Brake, Rebeccah R Riley, Stefan Duensing, Jeffrey M Arbeit, Dissection of Human Papillomavirus E6 and E7 Function in Transgenic Mouse Models of Cervical Carcinogenesis Cancer Research. ,vol. 63, pp. 4862- 4871 ,(2003)
Donald J. Tindall, Akira Yokomizo, Ming Mai, Wanguo Liu, Chiping Qian, David I. Smith, Ping Yang, Activation of p73 silent allele in lung cancer Cancer Research. ,vol. 58, pp. 2347- 2349 ,(1998)
Massimo Tommasino, Rosita Accardi, Sandra Caldeira, Wen Dong, Ilaria Malanchi, Anouk Smet, Ingeborg Zehbe, The role of TP53 in Cervical carcinogenesis Human Mutation. ,vol. 21, pp. 307- 312 ,(2003) , 10.1002/HUMU.10178
Jong-Sup Park, Eun-Joo Kim, Jung-Young Lee, Hong-Sig Sin, Sung-Eun Namkoong, Soo-Jong Um, Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins. International Journal of Cancer. ,vol. 91, pp. 822- 827 ,(2001) , 10.1002/1097-0215(200002)9999:9999<::AID-IJC1130>3.0.CO;2-0
Sandra Costa, Rui Medeiros, André Vasconcelos, Daniela Pinto, Carlos Lopes, A slow acetylator genotype associated with an increased risk of advanced cervical cancer. Journal of Cancer Research and Clinical Oncology. ,vol. 128, pp. 678- 682 ,(2002) , 10.1007/S00432-002-0391-9
Xingming Chen, Erich M. Sturgis, Carol J. Etzel, Qingyi Wei, Guojun Li, p73G4C14-to-A4T14 polymorphism and risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers Cancer. ,vol. 113, pp. 3307- 3314 ,(2008) , 10.1002/CNCR.23976
Hugo Sousa, Alexandra M. Santos, Raquel Catarino, Daniela Pinto, Andre´ Vasconcelos, Carlos Lopes, Eduardo Breda, Rui Medeiros, Linkage of TP53 codon 72 pro/pro genotype as predictive factor for nasopharyngeal carcinoma development. European Journal of Cancer Prevention. ,vol. 15, pp. 362- 366 ,(2006) , 10.1097/00008469-200608000-00010
Yoshimitsu Niwa, Nobuyuki Hamajima, Yoshiko Atsuta, Kazuhito Yamamoto, Akiko Tamakoshi, Toshiko Saito, Kaoru Hirose, Toru Nakanishi, Akihiro Nawa, Kazuo Kuzuya, Kazuo Tajima, Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical cancer in Japanese. Cancer Letters. ,vol. 205, pp. 55- 60 ,(2004) , 10.1016/J.CANLET.2003.11.014