A Case of Superwarfarin Poisoning Due to Repetitive Occupational Dermal Rodenticide Exposure in a Worker.

作者: Narlı Zehra Özdemir , Uğur Şahin , Mustafa Merter , Mehmet Gündüz , Berna Ateşağaoğlu

DOI: 10.4274/TJH.2015.0433

关键词:

摘要: Superwarfarin poisoning is usually due to chronic occult small-dose exposures and can easily be misdiagnosed may lead serious complications. The diagnosis confirmed by a concordant history analyses of blood urine specimens with the liquid chromatography tandem mass spectrometry (LC-MS/MS) technique. Several months continuous treatment high doses daily oral vitamin K, as well other supportive measures, are warranted, especially when repeated laboratory measurements help predict period not available. In this paper, case superwarfarin repetitive occupational dermal exposure commercial rodenticides presented.

参考文章(8)
Servet Altay, Huseyin Altug Cakmak, Gulsah Cemiloglu Boz, Sinan Koca, Yalcin Velibey, Prolonged coagulopathy related to coumarin rodenticide in a young patient: superwarfarin poisoning. Cardiovascular Journal of Africa. ,vol. 23, pp. 9- 11 ,(2012) , 10.5830/CVJA-2012-051
JN Weitzel, JA Sadowski, BC Furie, R Moroose, H Kim, ME Mount, MJ Murphy, B Furie, Surreptitious Ingestion of a Long-Acting Vitamin K Antagonist/Rodenticide, Brodifacoum: Clinical and Metabolic Studies of Three Cases Blood. ,vol. 76, pp. 2555- 2559 ,(1990) , 10.1182/BLOOD.V76.12.2555.BLOODJOURNAL76122555
Steffen Boettcher, Alexander Wacker, Klaus Moerike, Hans-Georg Kopp, Karl Jaschonek, Thomas Grobosch, Lothar Kanz, Helmut R. Salih, Acquired coagulopathy caused by intoxication with the superwarfarin-type anticoagulant rodenticide flocoumafen. European Journal of Haematology. ,vol. 86, pp. 173- 175 ,(2011) , 10.1111/J.1600-0609.2010.01550.X
M. Vogeser, K. Parhofer, Liquid chromatography tandem-mass spectrometry (LC-MS/MS)--technique and applications in endocrinology. Experimental and Clinical Endocrinology & Diabetes. ,vol. 115, pp. 559- 570 ,(2007) , 10.1055/S-2007-981458
Joseph E. Spahr, J. Scott Maul, George M. Rodgers, Superwarfarin poisoning: a report of two cases and review of the literature. American Journal of Hematology. ,vol. 82, pp. 656- 660 ,(2007) , 10.1002/AJH.20784
V. VANDENBROUCKE, A. BOUSQUET-MELOU, P. De BACKER, S. CROUBELS, Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration Journal of Veterinary Pharmacology and Therapeutics. ,vol. 31, pp. 437- 445 ,(2008) , 10.1111/J.1365-2885.2008.00979.X
J. E. Schaff, M. A. Montgomery, An HPLC–HR-MS-MS Method for Identification of Anticoagulant Rodenticides in Blood Journal of Analytical Toxicology. ,vol. 37, pp. 321- 325 ,(2013) , 10.1093/JAT/BKT036
Rapiti N, Govender P, Mahomed R, Bassa F, Kenoyer Dg, Poovalingam, Superwarfarin poisoning--a report of 4 cases. South African Medical Journal. ,vol. 92, pp. 874- ,(2002)