Role of Sam68 in Post-Transcriptional Gene Regulation

作者: Flora Sánchez-Jiménez , Víctor Sánchez-Margalet

DOI: 10.3390/IJMS141223402

关键词:

摘要: The STAR family of proteins links signaling pathways to various aspects post-transcriptional regulation and processing RNAs. Sam68 belongs this class heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing RNA-binding that also contains some domains predicted bind critical components in signal transduction pathways. In response phosphorylation other modifications, has been shown have the ability link downstream effects regulating RNA metabolism, including transcription, alternative splicing or transport. addition its function as a docking protein pathways, prototypic identified nuclear localization take part formation both cytosolic multi-molecular complexes such bodies stress granules. Coupling with targets, may play role differential expression mRNA translation according internal external signals, thus mediating important physiological functions, cell death, proliferation differentiation.

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