摘要: Cortical maturation is associated with a series of developmental programs encompassing neuronal and network-driven patterns. Thus, voltage-gated synapse-driven ionic currents are very different in immature adult neurons slower kinetics the former than latter. These features neuron stage dependent. GABA, which main inhibitory neurotransmitter brain, depolarizes excites its actions thought to exert trophic role processes. Networks follow parallel sequence calcium followed by plateaux patterns vitro. In vivo, early activity exhibits discontinuous temporal organization alternating bursts. Early cortical driven sensory input from periphery providing basis for activity-dependent modulation networks formation. notably excitatory GABA underlie high susceptibility seizures. Alterations these sequences play central malformations, migration disorders neurological sequelae.
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