Caspase 3 activation is essential for efficient influenza virus propagation

摘要: Apoptosis is a hallmark event observed upon infection with many viral pathogens, including influenza A virus. The apoptotic process executed by proteolytic system consisting of family cysteinyl proteases, termed caspases. Since the consequences apoptosis induction and caspase activation for outcome an virus are not clear, we have addressed this issue interfering expression or function major virus-induced effector, 3. Surprisingly, propagation was strongly impaired in presence inhibitor that blocks 3 cells where partially knocked down small RNAs. Consistent these findings, poor replication efficiencies viruses deficient could be boosted 30-fold ectopic protein. Mechanistically, block appeared to due retention RNP complexes nucleus, preventing formation progeny particles. Our findings indicate during onset crucial efficient propagation.