Visual paper-based sensor for the highly sensitive detection of caffeine in food and biological matrix based on CdTe-nano ZnTPyP combined with chemometrics.

摘要: Caffeine naturally occurs in tea and cocoa, which is also used as an additive beverages has pharmacological effects such refreshing, antidepressant, digestion promotion, but excessive caffeine can cause harm to the human body. In this work, based on specific response between nano zinc 5, 10, 15, 20-tetra(4-pyridyl)-21H-23H-porphine (nano ZnTPyP)-CdTe quantum dots (QDs) caffeine, combined with chemometrics, a visual paper-based sensor was constructed for rapid on-site detection of caffeine. The fluorescence QDs be quenched by ZnTPyP. When added system, it pull ZnTPyP off surface achieve recovery through electrostatic attraction nitrogen/zinc coordination. range 5 × 10−11~3 × 10−9 mol L−1, limit 1.53 × 10−11 mol L−1 (R2 = 0.9990) (S/N = 3). The paper-based exhibits good results real samples, water, cell culture fluid, newborn bovine serum, plasma. Therefore, expected applied instrument-free food biological samples. Graphical abstract